James M McKim, PhD

James M McKim, PhD
James M McKim, PhD

Research Associate Professor, Department of Biomedical Sciences

Contact Information

Email:

Biosketch

James McKim, PhD, is founder and president of IONTOX, a biotechnology company founded in 2014 dedicated to providing expertise to the area of in vitro toxicology, with a mission to build improved methods for predicting human adverse effects from chemical exposure. IONTOX offers advanced in vitro solutions that promise to increase the reliability of in vitro toxicology. This in-turn will reduce animal usage, improve the success of new drug candidates, and provide an advanced method of understanding systemic toxicity.

Dr. McKim is a graduate of Florida Technical College in Orlando, Florida. He earned his doctorate in biochemical and molecular toxicology from Oregon State University in Corvallis, Oregon, and also completed a postdoctoral fellowship in cellular and molecular toxicology with University of Kansas Medical Center in Kansas City, Kansas. Prior to founding IONTOX, he was founder, president, and CEO for CeeTox, and a senior research advisor with Pharmacia, serving as group leader for predictive toxicology.

  • Education and Training
    • Postdoctoral Fellowship 1992, Cellular and Molecular Toxicology, Medical Center, University of Kansas
    • PhD 1989, Biochemical and Molecular Toxicology, Oregon State University
    • BS 1982, Environmental Science, Florida Technical College
    • AS 1982, Ocean Engineering, Florida Technical College

  • Research
    • Toxicology

  • Publications

    • McKim J.M., Austin D.J., Sprando R., Hermansky S., Mattes W., Fitzpatrick S. Developing Kinetic and Organ Toxicity Data with a Novel In Vitro Human-Based Multiple Organ MPS: Acrylamide as a Case Study Applied In Vitro Toxicology. 2024;10(2):33-42.

    • McKim J., Willoughby J., Blakemore W., Weiner M. A Critical Review of 'A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity (Nutr. Healthy Aging. 2017; 4(2): 181-192).' Nutrition and Healthy Aging. 2019;5(2):149-158.

    • McKim J.M., Willoughby J.A., Blakemore W.R., Weiner M.L. Critical Reviews in Food Science and Nutrition. 2019;59(19):3054-3073.

    • Weiner M., McKim J. Food and Function. 2019;10(3):1760-1762.

    • Willoughby J.A., Brown M., Jadia R., Ebendick-Corpus B.E., Hibbard N., McKim J.M., Hess B. Assessment of the osteopromotive potential of a novel biocompatible mineral-organic adhesive bone cement in the microgravity of space and on earth Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 2019;40:428.

    • Myers D.K., Goldberg A.M., Poth A., Wolf M.F., Carraway J., McKim J., Coleman K.P., Hutchinson R., Brown R., Krug H.F., Bahinski A., Hartung T. Altex. 2017;34(4):479-500.

    • Weiner M., McKim J., Blakemore W. Food and Chemical Toxicology. 2017;107:208-214.

    • McKim J.M., Baas H., Rice G.P., Willoughby J.A., Weiner M.L., Blakemore W. Food and Chemical Toxicology. 2016;96:1-10.

    • Luechtefeld T., Maertens A., Mckim J.M., Hartung T., Kleensang A., Sá-Rocha V. Journal of Applied Toxicology. 2015;35(11):1361-1371.

    • McKim J.M., Wilga P.C., Pregenzer J.F., Blakemore W.R. Food and Chemical Toxicology. 2015;78:153-158.

    • Leist M., Hasiwa N., Rovida C., Daneshian M., Basketter D., Kimber I., Clewell H., Gocht T., Goldberg A., Busquet F., Rossi A.M., Schwarz M., Stephens M., Taalman R., Knudsen T.B., McKim J., Harris G., Pamies D., Hartung T. Altex. 2014;31(3):341-356.

    • McKim J. Critical Reviews in Toxicology. 2014;44(3):211-243.

    • Casas J.W., Lewerenz G.M., Rankin E.A., Willoughby J.A., Blakeman L.C., McKim J.M., Coleman K.P. Toxicology in Vitro. 2013;27(8):2175-2183.

    • Magee T.V., Brown M.F., Starr J.T., Ackley D.C., Abramite J.A., Aubrecht J., Butler A., Crandon J.L., Dib-Hajj F., Flanagan M.E., Granskog K., Hardink J.R., Huband M.D., Irvine R., Kuhn M., Leach K.L., Li B., Lin J., Luke D.R., Macvane S.H., Miller A.A., McCurdy S., McKim J.M., Nicolau D.P., Nguyen T.T., Noe M.C., O'Donnell J.P., Seibel S.B., Shen Y., Stepan A.F., Tomaras A.P., Wilga P.C., Zhang L., Xu J., Chen J.M. Journal of Medicinal Chemistry. 2013;56:5079-5093.

    • Yager J.W., Gentry P.R., Thomas R.S., Pluta L., Efremenko A., Black M., Arnold L.L., McKim J.M., Wilga P., Gill G., Choe K.Y., Clewell H.J. Environmental and Molecular Mutagenesis. 2013;54(2):82-98.

    • Basketter D.A., Clewell H., Kimber I., Rossi A., Blaauboer B., Burrier R., Daneshian M., Eskes C., Goldberg A., Hasiwa N., Hoffmann S., Jaworska J., Knudsen T.B., Landsiedel R., Leist M., Locke P., Maxwell G., McKim J., McVey E.A., Ouédraogo G., Patlewicz G., Pelkonen O., Roggen E., Rovida C., Ruhdel I., Schwarz M., Schepky A., Schoeters G., Skinner N., Trentz K., Turner M., Vanparys P., Yager J., Zurlo J., Hartung T. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing Altex. 2012;29(1):5-91.

    • Basketter D.A., Clewell H., Kimber I., Rossi A., Blaauboer B., Burrier R., Daneshian M., Eskes C., Goldberg A., Hasiwa N., Hoffmann S., Jaworska J., Knudsen T.B., Landsiedel R., Leist M., Locke P., Maxwell G., McKim J., McVey E.A., Ouédraogo G., Patlewicz G., Pelkonen O., Roggen E., Rovida C., Ruhdel I., Schwarz M., Schepky A., Schoeters G., Skinner N., Trentz K., Turner M., Vanparys P., Yager J., Zurlo J., Hartung T. ALTEX. 2012;29(1):3-91.

    • McKim J.M., Keller D.J., Gorski J.R. Cutaneous and Ocular Toxicology. 2012;31(4):292-305.

    • Hartung T., Blaauboer B.J., Bosgra S., Carney E., Coenen J., Conolly R.B., Corsini E., Green S., Faustman E.M., Gaspari A., Hayashi M., Hayes A.W., Hengstler J.G., Knudsen L.E., Knudsen T.B., McKim J.M., Pfaller W., Roggen E.L. Altex. 2011;28(3):183-209.

    • Lapchak P.A., McKim J.M. CeeToxâ„¢ Analysis of CNB-001 a Novel Curcumin-Based Neurotrophic/Neuroprotective Lead Compound to Treat Stroke: Comparison with NXY-059 and Radicut Translational Stroke Research. 2011;2(1):51-59.

    • McKim J.M. Combinatorial Chemistry and High Throughput Screening. 2010;13(2):188-206.

    • McKim J.M., Keller D.J., Gorski J.R. Cutaneous and Ocular Toxicology. 2010;29(3):171-192.

    • Liguori M.J., Anderson M.G., Bukofzer S., McKim J., Pregenzer J.F., Retief J., Spear B.B., Waring J.F. Hepatology. 2005;41(1):177-186.

    • Watson R.E., McKim J.M., Cockerell G.L., Goodman J.I. Toxicological Sciences. 2004;79(1):178-188.

    • Cockerell G.L., McKim J.M., Vonderfecht S.L. Toxicologic Pathology. 2002;30(1):4-7.

    • Sarangapani R., Teeguarden J., Plotzke K., McKim J., Andersen M. Toxicological Sciences. 2002;67(2):159-172.

    • McKim J., Wilga P., Breslin W., Plotzke K., Gallavan R., Meeks R. Toxicological Sciences. 2001;63(1):37-46.

    • McKim J.M., Kolesar G.B., Jean P.A., Meeker L.S., Wilga P.C., Schoonhoven R., Swenberg J.A., Goodman J.I., Gallavan R.H., Meeks R.G. Toxicology and Applied Pharmacology. 2001;172(2):83-92.

    • McKim J., Wilga P., Kolesar G., Choudhuri S., Madan A., Dochterman L., Breen J., Parkinson A., Mast R., Meeks R. Toxicological Sciences. 1998;41(1):29-41.

    • Choudhuri S., McKim J., Klaassen C. BBA - Molecular Basis of Disease. 1994;1225(2):171-179.

    • Klaassen C.D., Choudhuri S., McKim J.M., Lehman-McKeeman L.D., Kershaw W.C. Environmental Health Perspectives. 1994;102(SUPPL. 3):141-146.

    • Choudhuri S., McKim J.M., Klaassen C.D. Differential expression of the metallothionein gene in liver and brain of mice and rats Toxicology and Applied Pharmacology. 1993;119(1):1-10.

    • Kreppel H., Bauman J.W., Liu J., Mckim J.M., Klaassen C.D. Toxicological Sciences. 1993;20(2):184-189.

    • Bauman J.W., Madhu C., McKim J.M., Liu Y., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;117(2):233-241.

    • Bauman J.W., McKim J.M., Liu J., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;114(2):188-196.

    • Choudhuri S., McKim J.M., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;115(1):64-71.

    • Liu J., McKIM J.M., Liu Y.P., Klaassen C.D. In Vitro Cellular & Developmental Biology - Animal. 1992;28(5):320-326.

    • McKim J.M., Choudhuri S., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;116(1):117-124.

    • McKim J.M., Liu J., Liu Y.P., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;112(2):324-330.

    • McKim J.M., Liu J., Liu Y.P., Klaassen C.D. Toxicology and Applied Pharmacology. 1992;112(2):318-323.

    • Kuehl D.W., Eisenschenk L., Naumann S., Johnson R.D., Regal R., Barnidge P., McKim J. Bulletin of Environmental Contamination and Toxicology. 1991;46(5):713-719.

    • McKim J., Marien K., Schaup H., Selivonchick D. Lipids. 1991;26(7):521-525.

    • McKim J., Schaup H., Marien K., Selivonchick D. Lipids. 1989;24(3):187-192.